After being forced into marriage with Viper in previous issues, Wolverine finds himself climbing the Himalayas in search of evidence of a deadly virus. Viper recounts that she had already sent a team of twelve Hydra agents to recover the virus, but only three had returned, each of whom have been infected. Now, the disease is loose on the streets of Madripoor, and unless Wolverine can find the source of the virus, no antidote will be synthesized in time before it spreads across the entire world.